Shadab Shireen
Bombay Hospital Institute of Medical sciences and Research Centre, India
Title: Diamond-gardner syndrome
Biography
Biography: Shadab Shireen
Abstract
Diamond-Gardner Syndrome or autoerythocyte sensitization is a rare syndrome characterised by spontaneous development of painful edematous skin lesions progressing to ecchymosis over the next 24 hours. Severe stress and emotional trauma always precede the skin lesion. It is regarded primarily as an autoimmune vasculopathy with sensitization to phosphatidyl-serine, a component of erythrocyte stroma.
We present here a case of 15 years old girl who presented with multiple ecchymotic patches over body. Baseline biochemical, hematological and immunological investigations were normal. Skin biopsy showed no evidence of vasculitis. All routine coagulation investigations were normal. Diagnosis of Gardner-Diamond syndrome was made clinicaly, it was therefore diagnosis of exclusion. A high index of suspicion was necessary to make the diagnosis.